P311 promotes type II transforming growth factor-β receptor mediated fibroblast activation and granulation tissue formation in wound healing.

ABSTRACT:

Background

P311, a highly conserved 8 kDa intracellular protein, has recently been reported to play an important role in aggravating hypertrophic scaring by promoting the differentiation and secretion of fibroblasts. Nevertheless, how P311 regulates the differentiation and function of fibroblasts to affect granulation tissue formation remains unclear. In this work, we studied the underlying mechanisms via which P311 affects fibroblasts and promotes acute skin wound repair.

Methods

To explore the role of P311, both in vitro and in vivo wound-healing models were used. Full-thickness skin excisional wounds were made in wild-type and P311^-/- C57 adult mice. Wound healing rate, re-epithelialization, granulation tissue formation and collagen deposition wer

SUBMITTER: Wang J 

PROVIDER: S-EPMC9562783 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature