Bioinformatic-based approach for mutagenesis of plant immune Tm-2² receptor to confer resistance against tomato brown rugose fruit virus (ToBRFV).

ABSTRACT: Nucleotide-binding leucine-rich repeat (NLR) plant immune receptors mediate the recognition and activation of defense signaling pathways in response to intra- and extracellular pathogens. Several NLR such as Tm-2 and Tm-2² have been introgressed into commercial solanaceous varieties to confer protection against different tobamoviruses. Particularly, Tm-2² was used during recent decades to confer resistance against tobacco mosaic virus, tomato mottle mosaic virus and tomato mosaic virus, which recognizes the viral movement protein (MP). However, tomato brown rugose fruit virus(ToBRFV), a novel tobamovirus, can avoid the protection conferred by Tm-2² due to the presence of key substitutions in the MP. The aim of this work was to identify the key amino acid re

SUBMITTER: Rivera-Marquez K 

PROVIDER: S-EPMC9562835 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature