The "Sweet Spot" of Targeting Tumor Metabolism in Ovarian Cancers.

ABSTRACT: The objective of this review is to explore the metabolomic environment of epithelial ovarian cancer that contributes to chemoresistance and to use this knowledge to identify possible targets for therapeutic intervention. The Warburg effect describes increased glucose uptake and lactate production in cancer cells. In ovarian cancer, we require a better understanding of how cancer cells reprogram their glycogen metabolism to overcome their nutrient deficient environment and become chemoresistant. Glucose metabolism in ovarian cancer cells has been proposed to be influenced by altered fatty acid metabolism, oxidative phosphorylation, and acidification of the tumor microenvironment. We investigate several markers of altered metabolism in ovarian cancer including hypoxia-induced factor 1, VEGF,

SUBMITTER: Tondo-Steele K 

PROVIDER: S-EPMC9562887 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature