Probing patterning in microbial consortia with a cellular automaton for spatial organisation.

ABSTRACT: Microbial consortia exhibit spatial patterning across diverse environments. Since probing the self-organization of natural microbial communities is limited by their inherent complexity, synthetic models have emerged as attractive alternatives. In this study, we develop novel frameworks of bacterial communication and explore the emergent spatiotemporal organization of microbes. Specifically, we built quorum sensing-mediated models of microbial growth that are utilized to characterize the dynamics of communities from arbitrary initial configurations and establish the effectiveness of our communication strategies in coupling the growth rates of microbes. Our simulations indicate that the behavior of quorum sensing-coupled consortia can be most effectively modulated by the rates of secretion o

SUBMITTER: Venkatraghavan S 

PROVIDER: S-EPMC9563066 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature