Tumor-Associated Neutrophils in Colorectal Cancer Development, Progression and Immunotherapy.

ABSTRACT: The colorectal-cancer (CRC) incidence rate and mortality have remained high for several years. In recent years, immune-checkpoint-inhibitor (ICI) therapy has rapidly developed. However, it is only effective in a few CRC patients with microsatellite-instability-high (MSI-H) or mismatch-repair-deficient (dMMR) CRC. How to improve the efficiency of ICI therapy in CRC patients with microsatellite stability (MSS) remains a huge obstacle. Tumor-associated neutrophils (TANs), which are similar to macrophages, also have N₁ and N₂ phenotypes. They can be recruited and polarized through different cytokines or chemokines, and then play an antitumor or tumor-promoting role. In CRC, we find that the prognostic significance of TANs is still controversial. In this review, we describ

SUBMITTER: Zheng W 

PROVIDER: S-EPMC9563115 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature