VEGF to CITED2 ratio predicts the collateral circulation of acute ischemic stroke.

ABSTRACT:

Objective

The research objective was to evaluate the predicting role of the vascular endothelial growth factor to CBP/P300-interacting transactivator with Glu/Asp-rich C-terminal domain 2 Ratio (VEGF/CITED2) from peripheral blood mononuclear cells (PBMCs) in the collateral circulation of acute ischemic stroke (AIS).

Methods

In an observational study of patients with AIS, the western blot was applied to test the protein expression of VEGF and CITED2. Then, we calculated the VEGF/CITED2 and collected other clinical data. Binary logistic regression analysis between collateral circulation and clinical data was performed. Finally, receiver operating characteristic (ROC) curve analysis was used to explore the predictive value of VEGF/CITED2.

Results

A total of 67 patients w

SUBMITTER: Lu M 

PROVIDER: S-EPMC9563238 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature