Magnesium sulfate pharmacokinetics after intramuscular dosing in women with preeclampsia

ABSTRACT:

BACKGROUND

Current intramuscular magnesium dosing regimens in low and middle-income countries are based on indirect absorption parameters to inform pharmacokinetic and pharmacodynamic response.

OBJECTIVE

To determine if therapeutic serum magnesium levels are obtained in women with severe preeclampsia receiving intramuscular administration of magnesium sulfate using the Pritchard regimen and to compare the key pharmacokinetic variables to those previously published.

STUDY DESIGN

Serum magnesium levels were obtained at multiple time points at baseline and after magnesium sulfate administration from women with severe preeclampsia receiving the standard Pritchard regimen for seizure prophylaxis at Bayero University, Kano, Nigeria. The pharmacokinetic profiles were co

SUBMITTER: Brookfield K 

PROVIDER: S-EPMC9563381 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature