Characterization of exogenous αSN response genes and their relation to Parkinson's disease using network analyses.

ABSTRACT: Despite extensive research, the molecular mechanisms underlying the toxicity of αSN in Parkinson's disease (PD) pathology are still poorly understood. To address this, we used a microarray dataset to identify genes that are induced and differentially expressed after exposure to toxic αSN aggregates, which we call exogenous αSN response (EASR) genes. Using systems biology approaches, we then determined, at multiple levels of analysis, how these EASR genes could be related to PD pathology. A key result was the identification of functional connections between EASR genes and previously identified PD-related genes by employing the proteins' interactions networks and 9 brain region-specific co-expression networks. In each brain region, co-expression modules of EASR genes were enriched for

SUBMITTER: Nayeri Z 

PROVIDER: S-EPMC9563388 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature