Application of multiple testing procedures for identifying relevant comorbidities, from a large set, in traumatic brain injury for research applications utilizing big health-administrative data.

ABSTRACT:

Background

Multiple testing procedures (MTP) are gaining increasing popularity in various fields of biostatistics, especially in statistical genetics. However, in injury surveillance research utilizing the growing amount and complexity of health-administrative data encoded in the International Statistical Classification of Diseases and Related Health Problems 10th Revision (ICD-10), few studies involve MTP and discuss their applications and challenges.

Objective

We aimed to apply MTP in the population-wide context of comorbidity preceding traumatic brain injury (TBI), one of the most disabling injuries, to find a subset of comorbidity that can be targeted in primary injury prevention.

Methods

In total, 2,600 ICD-10 codes were used to assess the associations between TB

SUBMITTER: Jana S 

PROVIDER: S-EPMC9563390 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature