Time Trend and Association of Early-Onset Colorectal Cancer with Diverticular Disease in the United States: 2010-2021.

ABSTRACT:

Purpose

To examine time trends of incidence rates of EOCRC from 2010 to 2021 among patients with and without diverticular disease and to examine whether diverticular disease is associated with increased risk of EOCRC.

Methods

This is a retrospective cohort study of 46,179,351 young adults aged 20-49, including 298,117 with diverticular disease. We examined yearly incidence rate of first diagnosis of EOCRC from 2010 through 2021 among patients with and without diverticular disease. The 5-year risk of EOCRC among patients with pre-existing diverticular disease was compared to propensity-matched patients without diverticular disease and EOCRC and odds ratio (OR) and 95% confidence interval (CI) were calculated.

Results

The yearly incidence rate of new diagnosis of EOCRC

SUBMITTER: Wang L 

PROVIDER: S-EPMC9563394 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature