Ontology highlight
ABSTRACT:
SUBMITTER: Saber Cherif L
PROVIDER: S-EPMC9563397 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Saber Cherif Lynda L Diabasana Zania Z Perotin Jeanne-Marie JM Ancel Julien J Petit Laure M G LMG Devilliers Maëva A MA Bonnomet Arnaud A Lalun Nathalie N Delepine Gonzague G Maskos Uwe U Gosset Philippe P Polette Myriam M Muggeo Anaëlle A Guillard Thomas T Deslée Gaëtan G Dormoy Valérian V
Cells 20220920 19
Genome-wide association studies unveiled the associations between the single nucleotide polymorphism rs16969968 of CHRNA5, encoding the nicotinic acetylcholine receptor alpha5 subunit (α5SNP), and nicotine addiction, cancer, and COPD independently. Here, we investigated α5SNP-induced epithelial remodeling and inflammatory response in human COPD airways. We included 26 α5SNP COPD patients and 18 wild-type α5 COPD patients in a multi-modal study. A comparative histologic analysis was performed on ...[more]