TP53 mutation-associated immune infiltration and a novel risk score model in HNSCC.

ABSTRACT: In HNSCC, few studies have focused on the relationship between wild-type TP53 and mutant TP53-related immunity and prognosis. Our objective was to explore how TP53 mutation regulates the immunophenotype of HNSCC and thus affects the prognosis of HNSCC. Cox and Lasso regression were used to establish a prognostic model of TP53-related immune genes, on which basis a nomogram was used to establish a clinical prediction model, and ROC curves were further used to evaluate the effectiveness of the model. The risk of death in the TP53_WT group was only 0.68 times that in the TP53_Mut group (HR = 0.68, CI: 0.5-0.91, P < 0.05). T cells, CD8 T cells, cytotoxic lymphocytes, B lineage, NK cells, myeloid dendritic cells, and fibroblasts were significantly different between the TP53<

SUBMITTER: Kong W 

PROVIDER: S-EPMC9563607 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature