Adverse childhood experience referring to parental relationship is associated with the risk of alcohol dependence and with COMT Val158Met polymorphism, but out of gene-environment interactions

ABSTRACT:

Introduction

Gene-environment interactions (GxE) are considered to make a substantial impact on the risk of alcohol dependence (AD).

Objectives

The aim of the study: to test the associations between the functional polymorphism Val158Met (rs6265) in the catechol-O-methyl transferase (COMT) gene, affecting dopamine neurotransmission, and adverse childhood experiences (ACE) and their GxE interactions with AD risk.

Methods

The study included 149 AD inpatients (mean age 29.9 (SD=3.91), 16.1% females) and 201 healthy volunteers (23.3 (2.48), 30.1% females). The Adverse Childhood Experiences International Questionnaire (ACE-IQ) was used for assessing ACE. COMT Val158Met polymorphism was detected by RT-PCR.

Results

First, COMT Val158Met polymorphism was associat

SUBMITTER: Merkulova T 

PROVIDER: S-EPMC9563675 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature