Expam-high-resolution analysis of metagenomes using distance trees.

ABSTRACT:

Summary

Shotgun metagenomic sequencing provides the capacity to understand microbial community structure and function at unprecedented resolution; however, the current analytical methods are constrained by a focus on taxonomic classifications that may obfuscate functional relationships. Here, we present expam, a tree-based, taxonomy agnostic tool for the identification of biologically relevant clades from shotgun metagenomic sequencing.

Availability and implementation

expam is an open-source Python application released under the GNU General Public Licence v3.0. expam installation instructions, source code and tutorials can be found at https://github.com/seansolari/expam.

Supplementary information

Supplementary data are available at Bioinformatics online.

SUBMITTER: Solari SM 

PROVIDER: S-EPMC9563691 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature