The expression of stromal biomarkers in small papillary thyroid carcinomas.

ABSTRACT:

Background

The importance of stroma for tumor progression is recognized for many cancer types. In this study, we aim to evaluate the expression of types I (Col1) and IV (Col4) collagens, alpha-smooth muscle actin (a-SMA), and matrix metallopeptidase 9 (MMP-9) in the tumor stroma of small papillary thyroid carcinoma (PTC).

Material and methods

Twenty-five non-metastatic small PTCs (pT1N0) and nineteen metastatic small PTCs (pT1N1b) including corresponding metastatic lateral lymph nodes were selected and paraffinized tissue blocks retrieved. The samples were stained for Col1, COL4, a-SMA, and MMP-9 antibodies using immunohistochemistry. The expression of the stromal proteins was scored and analyzed based on the location, intensity, and distribution.

Results

Col1 and Col

SUBMITTER: Bayadsi H 

PROVIDER: S-EPMC9563774 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature