Association between childhood trauma and medication adherence among patients with major depressive disorder: the moderating role of resilience.

ABSTRACT:

Background

Suboptimal medication adherence is a major reason for failure in the management of major depressive disorder (MDD), childhood trauma might be an essential risk factor of suboptimal medication adherence. This study aimed to comprehensively explore the associations between different types of childhood trauma and medication adherence among patients with MDD, and to test whether resilience has moderating effects on the foregoing associations.

Methods

Participants were from the Depression Cohort in China (ChiCTR registry number 1900022145), 282 MDD patients with completed both baseline and 12-weeks follow-up investigations were included in this study. The diagnosis of MDD was assessed by trained psychiatrists using the Mini-International Neuropsychiatric Interview (M.I

SUBMITTER: Wang H 

PROVIDER: S-EPMC9563806 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature