Childhood Cardiovascular Risk Factors and Adult Cardiovascular Events.

ABSTRACT:

Background

Childhood cardiovascular risk factors predict subclinical adult cardiovascular disease, but links to clinical events are unclear.

Methods

In a prospective cohort study involving participants in the International Childhood Cardiovascular Cohort (i3C) Consortium, we evaluated whether childhood risk factors (at the ages of 3 to 19 years) were associated with cardiovascular events in adulthood after a mean follow-up of 35 years. Body-mass index, systolic blood pressure, total cholesterol level, triglyceride level, and youth smoking were analyzed with the use of i3C-derived age- and sex-specific z scores and with a combined-risk z score that was calculated as the unweighted mean of the five risk z scores. An algebraically comparable adult combined-risk z score (before

SUBMITTER: Jacobs DR 

PROVIDER: S-EPMC9563825 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature