Adipose Tissue Wasting as a Determinant of Pancreatic Cancer-Related Cachexia.

ABSTRACT: Pancreatic cancer (PC) is the third leading cause of cancer-related death in the US, and its 5-year survival rate is approximately 10%. The low survival rates largely stem from diagnostic delay and the presence of significant adipose tissue and muscle wasting, commonly referred to as cachexia. Cachexia is present in nearly 80% of PC patients and is a key cause of poor response to treatment and about 20% of death in PC patients. However, there are few clinical interventions proven to be effective against PC-related cachexia. Different cancer types feature distinct secretome profiles and functional characteristics which would lead to cachexia development differently. Therefore, here we discuss affected tissues and potential mechanisms leading to cachexia in PC. We postulate that the most aff

SUBMITTER: Yu SY 

PROVIDER: S-EPMC9563866 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature