Association of Paraoxonase-1 Genotype and Phenotype with Angiogram Positive Coronary Artery Disease.

ABSTRACT:

Background

It has been shown that increased serum PON1 levels are protective against several disorders. Several single nucleotide polymorphisms (SNPs) of the PON1 gene have been reported to be associated with serum enzyme protein levels and activity.

Objective

To investigate the association of SNPs of PON1 and serum paraoxonase activity with coronary artery disease (CAD).

Methods

A total of 601 unrelated patients who underwent coronary angiography including those who had >50% stenosis (N=266) and those with <30% stenosis (N=335) were studied. The Paraoxonase gene rs662 and rs840560 SNPs were determined using the ARMS-PCR method and the rs705379 SNP was genotyped using PCR-RFLP analysis. Serum paraoxonase activity was measured using paraoxon as a substrate. A p v

SUBMITTER: Soflaei SS 

PROVIDER: S-EPMC9563872 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature