ROBUST INFERENCE WHEN COMBINING INVERSE-PROBABILITY WEIGHTING AND MULTIPLE IMPUTATION TO ADDRESS MISSING DATA WITH APPLICATION TO AN ELECTRONIC HEALTH RECORDS-BASED STUDY OF BARIATRIC SURGERY.

ABSTRACT: While electronic health records present a rich and promising data source for observational research, they are highly susceptible to missing data. For settings like these, Seaman et al. (Biometrics 68 (2012) 129-137) proposed a strategy wherein one handles missingness in some variables using inverse-probability weighting and others using multiple imputation. Seaman et al. (Biometrics 68 (2012) 129-137) show that Rubin's variance estimator for averaging results across datasets is asymptotically valid when the analysis and imputation models are correctly specified and the weights are either known or correctly specified. Modeled after the approach of Robins and Wang (Biometrika 87 (2000) 113-124), we propose a method for asymptotically valid inference

SUBMITTER: Thaweethai T 

PROVIDER: S-EPMC9563917 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature