Validating Discriminative Signatures for Obstructive Sleep Apnea in Exhaled Breath.

ABSTRACT: Rapid and reliable tools for the diagnosis and monitoring of obstructive sleep apnea (OSA) are currently lacking. Prior studies using a chemical analysis of exhaled breath have suggested the existence of an OSA-specific metabolic signature. Here, we validated this diagnostic approach and the proposed marker compounds, as well as their potential to reliably diagnose OSA. In this cross-sectional observational study, exhaled breath was analyzed using secondary electrospray ionization high-resolution mass spectrometry. The study cohort included untreated OSA patients, OSA patients treated with continuous positive airway pressure and healthy subjects. The robustness of previously reported OSA markers was validated based on detectability, significant differences between groups (Mann-Whitney U te

SUBMITTER: Streckenbach B 

PROVIDER: S-EPMC9563926 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature