Single-Cell Gene Expression Analysis Revealed Immune Cell Signatures of Delta COVID-19

ABSTRACT: The coronavirus disease 2019 (COVID-19) is accompanied by a cytokine storm with the release of many proinflammatory factors and development of respiratory syndrome. Several SARS-CoV-2 lineages have been identified, and the Delta variant (B.1.617), linked with high mortality risk, has become dominant in many countries. Understanding the immune responses associated with COVID-19 lineages may therefore aid the development of therapeutic and diagnostic strategies. Multiple single-cell gene expression studies revealed innate and adaptive immunological factors and pathways correlated with COVID-19 severity. Additional investigations covering host–pathogen response characteristics for infection caused by different lineages are required. Here, we performed single-cell transcriptome profiling of bl

SUBMITTER: Shaymardanov A 

PROVIDER: S-EPMC9563974 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature