Spontaneous transitions between amoeboid and keratocyte-like modes of migration.

ABSTRACT: The motility of adherent eukaryotic cells is driven by the dynamics of the actin cytoskeleton. Despite the common force-generating actin machinery, different cell types often show diverse modes of locomotion that differ in their shape dynamics, speed, and persistence of motion. Recently, experiments in Dictyostelium discoideum have revealed that different motility modes can be induced in this model organism, depending on genetic modifications, developmental conditions, and synthetic changes of intracellular signaling. Here, we report experimental evidence that in a mutated D. discoideum cell line with increased Ras activity, switches between two distinct migratory modes, the amoeboid and fan-shaped type of locomotion, can even spontaneously occur within the same cell. We obse

SUBMITTER: Moldenhawer T 

PROVIDER: S-EPMC9563996 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature