A pan-cancer mycobiome analysis reveals fungal involvement in gastrointestinal and lung tumors.

ABSTRACT: Fungal microorganisms (mycobiota) comprise a small but immunoreactive component of the human microbiome, yet little is known about their role in human cancers. Pan-cancer analysis of multiple body sites revealed tumor-associated mycobiomes at up to 1 fungal cell per 10⁴ tumor cells. In lung cancer, Blastomyces was associated with tumor tissues. In stomach cancers, high rates of Candida were linked to the expression of pro-inflammatory immune pathways, while in colon cancers Candida was predictive of metastatic disease and attenuated cellular adhesions. Across multiple GI sites, several Candida species were enriched in tumor samples and tumor-associated Candida DNA was predictive of decreased survival. The presence of Candida in human GI tumors was confirmed by external ITS seque

SUBMITTER: Dohlman AB 

PROVIDER: S-EPMC9564002 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature