Human cerebellum and corticocerebellar connections involved in emotional memory enhancement.

ABSTRACT: Emotional information is better remembered than neutral information. Extensive evidence indicates that the amygdala and its interactions with other cerebral regions play an important role in the memory-enhancing effect of emotional arousal. While the cerebellum has been found to be involved in fear conditioning, its role in emotional enhancement of episodic memory is less clear. To address this issue, we used a whole-brain functional MRI approach in 1,418 healthy participants. First, we identified clusters significantly activated during enhanced memory encoding of negative and positive emotional pictures. In addition to the well-known emotional memory-related cerebral regions, we identified a cluster in the cerebellum. We then used dynamic causal modeling and identified several cerebellar

SUBMITTER: Fastenrath M 

PROVIDER: S-EPMC9564100 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature