Nose-to-Brain: The Next Step for Stem Cell and Biomaterial Therapy in Neurological Disorders.

ABSTRACT: Neurological disorders are a leading cause of morbidity worldwide, giving rise to a growing need to develop treatments to revert their symptoms. This review highlights the great potential of recent advances in cell therapy for the treatment of neurological disorders. Through the administration of pluripotent or stem cells, this novel therapy may promote neuroprotection, neuroplasticity, and neuroregeneration in lesion areas. The review also addresses the administration of these therapeutic molecules by the intranasal route, a promising, non-conventional route that allows for direct access to the central nervous system without crossing the blood-brain barrier, avoiding potential adverse reactions and enabling the administration of large quantities of therapeutic molecules to the brain. Fina

SUBMITTER: Villar-Gomez N 

PROVIDER: S-EPMC9564248 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature