Microglia-Based Gene Expression Signature Highly Associated with Prognosis in Low-Grade Glioma.

ABSTRACT: Gliomas make up ~80% of malignant brain tumors in adults and are responsible for the majority of deaths from primary brain tumors. The glioma tumor microenvironment (TME) is a dynamic, heterogeneous mixture of extracellular matrix and malignant and non-malignant cells. Several ongoing clinical trials are evaluating the efficacy of therapies that target non-malignant cells, particularly immune cells. Consequently, a better understanding of the TME in glioma is pertinent. We utilized several gene expression datasets to evaluate the relationship between immune-related genes (IRGs) and patient prognosis. We generated microglia signatures using single-cell RNAseq data from human and mouse glioma cells to infer microglia abundance. Lastly, we built a LASSO Cox regression model that predicts pati

SUBMITTER: Schaafsma E 

PROVIDER: S-EPMC9564275 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature