Diagnostic Potential of microRNAs in Extracellular Vesicles Derived from Bronchoalveolar Lavage Fluid for Pneumonia-A Preliminary Report.

ABSTRACT: Current clinical needs require the development and use of rapid and effective diagnostic indicators to accelerate the identification of pneumonia and the process of microbiological diagnosis. MicroRNAs (miRNAs) in extracellular vesicles (EVs) have become attractive candidates for novel biomarkers to evaluate the presence and progress of many diseases. We assessed their performance as biomarkers of pneumonia. Patients were divided into the pneumonia group (with pneumonia) and the control group (without pneumonia). We identified and compared two upregulated miRNAs in EVs derived from bronchoalveolar lavage fluid (BALF-EVs) between the two groups (P_miR-17-5p = 0.009; P_miR-193a-5p = 0.031). Interestingly, in cell-debris pellets and EVs-free supernatants deri

SUBMITTER: Sun Y 

PROVIDER: S-EPMC9564323 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature