Comparing the development of cortex-wide gene expression patterns between two species in a common reference frame.

ABSTRACT: Advances in sequencing techniques have made comparative studies of gene expression a current focus for understanding evolutionary and developmental processes. However, insights into the spatial expression of genes have been limited by a lack of robust methodology. To overcome this obstacle, we developed methods and software tools for quantifying and comparing tissue-wide spatial patterns of gene expression within and between species. Here, we compare cortex-wide expression of RZRβ and Id2 mRNA across early postnatal development in mice and voles. We show that patterns of RZRβ expression in neocortical layer 4 are highly conserved between species but develop rapidly in voles and much more gradually in mice, who show a marked expansion in the relative size of the putativ

SUBMITTER: James SS 

PROVIDER: S-EPMC9564327 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature