Congenital anomalies and maternal age: A systematic review and meta-analysis of observational studies.

ABSTRACT:

Introduction

Several studies have reported on the maternal age-associated risks of congenital anomalies. However, there is a paucity of studies with comprehensive review of anomalies. We aimed to quantify the risk of birth defects in children born to middle-aged mothers compared with that in children born to young or older mothers.

Material and methods

We classified maternal ages into three groups: young (<20 years old), middle (20-34 years old) and older age (≥35 years old). Observational studies that met our age criteria were eligible for inclusion. The articles searched using the Embase and MEDLINE databases were those published from 1989 to January 21, 2021. The Newcastle-Ottawa scale was used to assess the risk of bias. If heterogeneity exceeded 50%, the random effect m

SUBMITTER: Ahn D 

PROVIDER: S-EPMC9564554 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature