Adjunctive azithromycin prophylaxis protects women from uterine cesarean scar defect: A randomized controlled trial.

ABSTRACT:

Introduction

Cesarean scar defect (CSD) is a long-term outcome of cesarean section (CS) and associated with numerous gynecological and obstetric problems. Previous studies indicate that infection may be a risk factor for CSD. Adjunctive azithromycin was shown to reduce the risk of postoperative infection in patients undergoing non-elective primary cesarean delivery in labor or after the rupture of membranes compared with standard antibiotic prophylaxis. This study investigated the protective effect of adjunctive azithromycin in combination with single-dose cephalosporin against CSD in women undergoing non-elective cesarean delivery.

Material and methods

A randomized, double-blind, controlled clinical trial was conducted in a University hospital in Shanghai, China. A total of

SUBMITTER: Huang D 

PROVIDER: S-EPMC9564557 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature