Gaussian curvature-driven direction of cell fate toward osteogenesis with triply periodic minimal surface scaffolds.

ABSTRACT: Leaf photosynthesis, coral mineralization, and trabecular bone growth depend on triply periodic minimal surfaces (TPMSs) with hyperboloidal structure on every surface point with varying Gaussian curvatures. However, translation of this structure into tissue-engineered bone grafts is challenging. This article reports the design and fabrication of high-resolution three-dimensional TPMS scaffolds embodying biomimicking hyperboloidal topography with different Gaussian curvatures, composed of body inherent β-tricalcium phosphate, by stereolithography-based three-dimensional printing and sintering. The TPMS bone scaffolds show high porosity and interconnectivity. Notably, compared with conventional scaffolds, they can reduce stress concentration, leading to increased mechanical strength. They ar

SUBMITTER: Yang Y 

PROVIDER: S-EPMC9564829 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature