Exploring the casual association between coffee intake and bladder cancer risk using Mendelian Randomization.

ABSTRACT: Objective: Several observational studies have suggested that coffee consumption is associated with a lower risk of bladder cancer. However, observational studies are susceptible to confounding factors and reverse causality. We used a two-sample Mendelian randomization (MR) method to assess the causal nature of this association. Methods: At the genome-wide significance level (p < 5 × 10^-8), 12 single nucleotide polymorphisms (SNPs) strongly associated with coffee consumption were used as instrumental variables (IVs). Summary-level data on genetic variation in bladder cancer were obtained from the United Kingdom biobank (420,838 samples) and FinnGen consortium (175,121 samples). Multiple MR methods were used. Heterogeneity and horizontal pleiotropy were detect

SUBMITTER: Deng Y 

PROVIDER: S-EPMC9565034 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature