Enhanced Uptake and Phototoxicity of C₆₀@albumin Hybrids by Folate Bioconjugation.

ABSTRACT: Fullerenes are considered excellent photosensitizers, being highly suitable for photodynamic therapy (PDT). A lack of water solubility and low biocompatibility are, in many instances, still hampering the full exploitation of their potential in nanomedicine. Here, we used human serum albumin (HSA) to disperse fullerenes by binding up to five fullerene cages inside the hydrophobic cavities. Albumin was bioconjugated with folic acid to specifically address the folate receptors that are usually overexpressed in several solid tumors. Concurrently, tetramethylrhodamine isothiocyanate, TRITC, a tag for imaging, was conjugated to C₆₀@HSA in order to build an effective phototheranostic platform. The in vitro experiments demonstrated that: (i) HSA disperses C₆₀ molecules in a p

SUBMITTER: Cantelli A 

PROVIDER: S-EPMC9565331 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature