Biocompatible Iron Oxide Nanoparticles for Targeted Cancer Gene Therapy: A Review.

ABSTRACT: In recent years, gene therapy has made remarkable achievements in tumor treatment. In a successfully cancer gene therapy, a smart gene delivery system is necessary for both protecting the therapeutic genes in circulation and enabling high gene expression in tumor sites. Magnetic iron oxide nanoparticles (IONPs) have demonstrated their bright promise for highly efficient gene delivery target to tumor tissues, partly due to their good biocompatibility, magnetic responsiveness, and extensive functional surface modification. In this review, the latest progress in targeting cancer gene therapy is introduced, and the unique properties of IONPs contributing to the efficient delivery of therapeutic genes are summarized with detailed examples. Furthermore, the diagnosis potentials and synergistic t

SUBMITTER: Zhang J 

PROVIDER: S-EPMC9565336 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature