Appendiceal microbiome in uncomplicated and complicated acute appendicitis: A prospective cohort study.

ABSTRACT:

Background

Uncomplicated and complicated acute appendicitis seem to be two different forms of this common abdominal emergency. The contribution of appendiceal microbiota to appendicitis pathogenesis has been suggested, but differences between uncomplicated and complicated appendicitis are largely unknown. We compared the appendiceal microbiota in uncomplicated and complicated acute appendicitis.

Methods

This prospective single-center clinical cohort study was conducted as part of larger multicenter MAPPAC trial enrolling adult patients with computed tomography or clinically confirmed uncomplicated or complicated acute appendicitis. The microbial composition of the appendiceal lumen was determined using 16S rRNA gene amplicon sequencing.

Results

Between April 11, 2017,

SUBMITTER: Vanhatalo S 

PROVIDER: S-EPMC9565418 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature