Concentration fluctuations in growing and dividing cells: Insights into the emergence of concentration homeostasis.

ABSTRACT: Intracellular reaction rates depend on concentrations and hence their levels are often regulated. However classical models of stochastic gene expression lack a cell size description and cannot be used to predict noise in concentrations. Here, we construct a model of gene product dynamics that includes a description of cell growth, cell division, size-dependent gene expression, gene dosage compensation, and size control mechanisms that can vary with the cell cycle phase. We obtain expressions for the approximate distributions and power spectra of concentration fluctuations which lead to insight into the emergence of concentration homeostasis. We find that (i) the conditions necessary to suppress cell division-induced concentration oscillations are difficult to achieve; (ii) mRNA concentrati

SUBMITTER: Jia C 

PROVIDER: S-EPMC9565450 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature