Octahedral Molybdenum Cluster-Based Nanomaterials for Potential Photodynamic Therapy.

ABSTRACT: Photo/radiosensitizers, such as octahedral molybdenum clusters (Mo₆), have been intensively studied for photodynamic applications to treat various diseases. However, their delivery to the desired target can be hampered by its limited solubility, low stability in physiological conditions, and inappropriate biodistribution, thus limiting the therapeutic effect and increasing the side effects of the therapy. To overcome such obstacles and to prepare photofunctional nanomaterials, we employed biocompatible and water-soluble copolymers based on N-(2-hydroxypropyl)methacrylamide (pHPMA) as carriers of Mo₆ clusters. Several strategies based on electrostatic, hydrophobic, or covalent interactions were employed for the formation of polymer-cluster constructs. Importantl

SUBMITTER: Tavares MR 

PROVIDER: S-EPMC9565569 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature