Association between breastfeeding, host genetic factors, and calicivirus gastroenteritis in a Nicaraguan birth cohort.

ABSTRACT:

Background

Norovirus and sapovirus are important causes of childhood acute gastroenteritis (AGE). Breastfeeding prevents AGE generally; however, it is unknown if breastfeeding prevents AGE caused specifically by norovirus and sapovirus.

Methods

We investigated the association between breastfeeding and norovirus or sapovirus AGE episodes in a birth cohort. Weekly data on breastfeeding and AGE episodes were captured during the first year of life. Stools were collected from children with AGE and tested by RT-qPCR for norovirus and sapovirus. Time-dependent Cox models estimated associations between weekly breastfeeding and time to first norovirus or sapovirus AGE.

Findings

From June 2017 to July 2018, 444 newborns were enrolled in the study. In the first year of life, 69

SUBMITTER: Vielot NA 

PROVIDER: S-EPMC9565698 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature