Tonic Endocannabinoid Levels Modulate Retinal Signaling.

ABSTRACT: The endocannabinoid (eCB) system is critically involved in the modulation of synaptic transmission in the central nervous system, playing an important role in the control of emotional responses, neurodevelopment and synaptic plasticity among other functions. The eCB system is also present in the retina, with studies indicating changes in function after application of cannabinoid receptor agonists, antagonists and in knockout models. Whether eCBs are tonically released in the retina and their physiological functions is, however, still unknown. We investigated the role of the eCB system in the modulation of response strength of retinal ganglion cells (RGCs) to light stimulation, their receptive field organization, contrast sensitivity and excitability properties by performing whole-cell patc

SUBMITTER: Yates CF 

PROVIDER: S-EPMC9566182 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature