Genetic Analysis Implicates Dysregulation of SHANK2 in Renal Cell Carcinoma Progression.

ABSTRACT: SH3 and multiple ankyrin repeat domains (SHANK) is a family of scaffold proteins that were first identified to be involved in balancing synaptic transmission via regulation of intracellular signalling crosstalk and have been linked to various cancers. However, the role of the SHANK genes in renal cell carcinoma (RCC) remains to be elucidated. In this study, we aimed to evaluate whether genetic variants in SHANK family genes affect the risk of RCC and survival of patients. A genetic association study was conducted using logistic regression and Cox regression analyses, followed by the correction for a false discovery rate (FDR), in 630 patients with RCC and controls. A pooled analysis was further performed to summarise the clinical relevance of SHANK gene expression in RCC. After adju

SUBMITTER: Chang CF 

PROVIDER: S-EPMC9566262 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature