Using molecular epidemiology to trace the history of the injection-related HIV epidemic in New York City, 1985-2019.

ABSTRACT:

Objective

Unintentional drug poisoning and overdose deaths in New York City (NYC) increased 175% between 2010 and 2017, partly due to the transition from noninjectable opioids to heroin injection. This transition has led to concern of a resurgent HIV epidemic among persons who inject drugs (PWID) in NYC. Thus, we sought to characterize HIV transmission dynamics in PWID.

Design

Genetic network analysis of HIV-1 public health surveillance data.

Methods

We analyzed HIV diagnoses reported to public health surveillance to determine the trajectory of the HIV epidemic among PWID in NYC, from 1985 through 2019. Genetic distance-based clustering was performed using HIV-TRACE to reconstruct transmission patterns among PWID.

Results

The majority of the genetic links to PW

SUBMITTER: Torian LV 

PROVIDER: S-EPMC9566884 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature