Cytometric analysis reveals an association between allergen-responsive natural killer cells and human peanut allergy.

ABSTRACT: Food allergies are a leading cause of anaphylaxis, and allergen-specific immune responses in both the innate and the adaptive immune system play key roles in its pathogenesis. We conducted a comprehensive phenotypic and functional investigation of immune cell responses from nonallergic (NA) and peanut allergic (PA) participants cultured with media alone or peanut protein and found, surprisingly, that NK cell activation was strongly associated with the immune response to allergen in PA participants. Peanut-responsive NK cells manifested a distinct expression pattern in PA participants compared with NA participants. Allergen-activated NK cells expressed both Th2 and immune regulatory cytokines, hinting at a potential functional role in mediating and regulating the Th2 allergic response. Depl

SUBMITTER: Zhou X 

PROVIDER: S-EPMC9566921 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature