Mast cell-derived factor XIIIA contributes to sexual dimorphic defense against group B streptococcal infections.

ABSTRACT: Invasive bacterial infections remain a major cause of human morbidity. Group B streptococcus (GBS) are Gram-positive bacteria that cause invasive infections in humans. Here, we show that factor XIIIA-deficient (FXIIIA-deficient) female mice exhibited significantly increased susceptibility to GBS infections. Additionally, female WT mice had increased levels of FXIIIA and were more resistant to GBS infection compared with isogenic male mice. We observed that administration of exogenous FXIIIA to male mice increased host resistance to GBS infection. Conversely, administration of a FXIIIA transglutaminase inhibitor to female mice decreased host resistance to GBS infection. Interestingly, male gonadectomized mice exhibited decreased sensitivity to GBS infection, suggesting a role for gonadal an

SUBMITTER: Piliponsky AM 

PROVIDER: S-EPMC9566924 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature