The impact of the oxytocin receptor gene (OXTR) on facial affect recognition in psychosis

ABSTRACT:

Introduction

Oxytocin is considered as potential treatment targeting social dysfunctions in psychoses. However, results of clinical trials are inconsistent which may be due to genetic variation in the oxytocin system involved in social information processing.

Objectives

To examine the effect of the OXTR polymorphism and its interaction with childhood adversity (CA) on facial affect recognition (FAR) in psychotic patients.

Methods

Patients with schizophrenic and affective psychotic disorders (n=934) completed a task that required labeling six basic and three social emotions. The polymorphisms rs53576 and rs7632287 within the OXTR locus were genotyped and dichotomized based on prior research. For 65% of the sample, information on CA defined as parental alcoholism o

SUBMITTER: Mikhailova V 

PROVIDER: S-EPMC9567007 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature