Effectiveness of BNT162b2 Vaccination During Pregnancy in Preventing Hospitalization for SARS-CoV-2 in Infants.

ABSTRACT:

Objective

To Assessthe clinical effectiveness of the BNT162b2 vaccine during pregnancy in preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hospitalizations of infants.

Study design

A retrospective, multicenter, 1:3 case-control (test-negative) study. Symptomatic hospitalized infants <6 months, with positive SARS-CoV-2 polymerase chain reaction (PCR) test between 1/3/2021-31/11/2021 were matched by age and time to negative controls, hospitalized with symptoms compatible with SARS-CoV-2 infection. Mothers were defined as fully vaccinated; received 2 doses of BNT162b2 with the second given 2 weeks to 6 months before delivery, or partially vaccinated; received only one dose or 2 doses with the second given >6 months or <2 weeks before delivery. Severe SARS

SUBMITTER: Danino D 

PROVIDER: S-EPMC9568274 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature