In Vivo Antimalarial Activity of the Leaf Extract of Osyris quadripartita Salzm. ex Decne and Its Major Compound (-) Catechin.

ABSTRACT:

Background

The leaves of Osyris quadripartita Salzm. ex Decne, endemic to Ethiopia, are traditionally used for the treatment of malaria. Previous phytochemical investigations of Osyris species showed the presence of flavonoids, anthracene derivatives, and sesquiterpene lactones as the main constituents. The aim of the present study was to investigate the antimalarial activity of the leaf extract of O. quadripartita and its isolated constituent against mice infected with Plasmodium berghei.

Methods

Isolation of a compound was carried out on silica gel column chromatography of the extract eluting with gradient mixtures of CHCl₃/MeOH. Structural elucidation of the isolated compound was achieved by ESI-MS and 1D-and 2D-NMR spectral data. Pe

SUBMITTER: Kemal T 

PROVIDER: S-EPMC9568338 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature