Association of ERCC1 rs11615 Polymorphism with the Risk of Cervical Cancer Especially in Chinese Populations: A Meta-Analysis.

ABSTRACT: Abnormalities of the ERCC1 gene can affect DNA repair pathways, thereby having a vital effect on genomic stability. A growing amount of case-control studies have focused on making an investigation of the association between ERCC1 rs11615 polymorphism and cervical cancer susceptibility. However, the controversial results have raised concerns. To draw a more accurate conclusion, six studies were elaborately selected from the electronic databases for this meta-analysis, with 753 cervical cancer cases and 851 healthy controls. We applied pooled ORs combined with 95% CIs to test the potential associations. Significant associations were revealed in Chinese populations (T vs C: OR = 1.557 and 95%CI = 1.234-1.966; TT vs CC: OR = 3.175 and 95%CI = 1.754-5.748; TT/CT vs CC: OR = 1.512 and 95%CI = 1.

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9568358 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature