Parallel detection of SARS-CoV-2 epitopes reveals dynamic immunodominance profiles of CD8⁺ T memory cells in convalescent COVID-19 donors.

ABSTRACT:

Objectives

High-magnitude CD8⁺ T cell responses are associated with mild COVID-19 disease; however, the underlying characteristics that define CD8⁺ T cell-mediated protection are not well understood. The antigenic breadth and the immunodominance hierarchies of epitope-specific CD8⁺ T cells remain largely unexplored and are essential for the development of next-generation broad-protective vaccines. This study identified a broad spectrum of conserved SARS-CoV-2 CD8⁺ T cell epitopes and defined their respective immunodominance and phenotypic profiles following SARS-CoV-2 infection.

Methods

CD8⁺ T cells from 51 convalescent COVID-19 donors were analysed for their ability to recognise 133 predicted and previously described SA

SUBMITTER: van den Dijssel J 

PROVIDER: S-EPMC9568370 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature