NMR-based metabolic profiling of children with premature adrenarche.

ABSTRACT:

Introduction

Premature adrenarche (PA) for long time was considered a benign condition but later has been connected to various diseases in childhood and adulthood which remains controversial.

Objective

To investigate the effect of premature adrenarche on the metabolic phenotype, and correlate the clinical and biochemical data with the metabolic profile of children with PA.

Methods

Nuclear magnetic resonance (NMR)-based untargeted and targeted metabolomic approach in combination with multivariate and univariate statistical analysis applied to study the metabolic profiles of children with PA. Plasma, serum, and urine samples were collected from fifty-two children with Idiopathic PA and forty-eight age-matched controls from the division of Pediatric Endocrinology of the

SUBMITTER: Matzarapi K 

PROVIDER: S-EPMC9568450 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature